Push-Through Test for Pharmaceutical Blister Packs
Pharmaceutical tablets and capsules are commonly packaged in blister packs that protect the enclosed tablets and capsules from moisture and contamination. This optimizes the product stability and maximizing its shelf-life. The two primary components of a blister pack are the rows of cavities, typically made of thermoplastic, and the lidding seals that can be made of paperboard, aluminum, or plastics. However, in pharmaceutical packages, aluminum foil is most frequently used. It is important for manufacturers to ensure that the blister pack does not break too easily but yet it needs to be brittle enough to allow consumers to break by hand in order to dispense the tablets or capsules.
We were asked to provide a solution to measure the force required to push a table through its blister pack. Our Engineered Solutions team designed a simple custom fixture to meet this application requirement. The top-down clamps are adjustable to suit different dimensions of blister packs and the lower base holder includes spacer plates with various cut out sizes to cater to different dimension tablets and capsules.
We performed the test using a 5965 table model frame and the 3®Bluehill Biomedical Materials and Medical Devices Application Module. We first fixed the blister pack onto the lower base holder with top-down clamps and then applied a force with a flat tipped probe (with a 10 mm diameter) at 20 mm/min to push the tablet out from the blister pack.
We recorded the maximum force required to press the tablet out from the blister pack in Bluehill 3 Software. From this, we can determine if the lidding material is too brittle or if the adhesive strength between the lidding backing and the plastic-formed cavity is strong enough.
5900 만능재료시험기는 정밀도, 내구성, 변화되는 요구사항에 유연하게 대처합니다. 작업자의 시험 경험을 향상시키고 시험의 효율성을 높이기 위한 표준 및 옵션들을 갖추고 있습니다. 100N에서 600k N에 이르는 용량을 시험할 수 있는 다양한 범위의 모델이 있습니다.
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